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Treating hospitalized, severely malnourished children with a lactose-free, reduced-carbohydrate milk formula doesn’t improve clinical outcomes, according to a study published in the open-access journal PLOS Medicine by Robert Bandsma, MD, PhD, of the Hospital for Sick Children in Toronto, Canada; James Berkley, MD, of the KEMRI/Wellcome Trust Research Programme in Kilifi, Kenya; and colleagues.

Children who are sick and have severe acute malnutrition have a high risk of death during their stay in the hospital. Diarrhea from malabsorption of sugars, and refeeding syndrome—a metabolic disturbance that occurs as a result of rapid reinstitution of nutrition—may both contribute to delayed recovery and early mortality.

Doctors and nutritionists have wondered whether giving alternative types of formula, such as lactose-free feeds (lactose is one of the sugars that may not be absorbed and can cause diarrhea) may be beneficial; these feeds are intermittently used and are expensive in resource-poor settings.

The study team redesigned the initial formula given to sick, severely malnourished children by eliminating lactose and reducing other sugars (carbohydrates) by about 30%, to reduce these risks while still providing sufficient vital energy and nutrients to children.

In a multicenter, double-blinded trial in Kenya and Malawi, hospitalized, sick, severely malnourished children with a median age of 16 months were randomized to receive the existing standard formula (418 participants) or the modified formula (425 participants).

The two groups didn’t differ significantly in terms of how long it took to stabilize their condition, as judged by recovery from their acute illness as well as metabolic stabilization evidenced by recovery of appetite. There were no differences in the numbers who died or suffered diarrhea between the two groups.

Importantly, biochemical analysis among the children in the study who had diarrhea suggested that, despite removing lactose and reducing the other carbohydrates, the lactose-free formula still presented a load of carbohydrates above that which the intestines could absorb.

According to the authors, the results support the ongoing use of the current milk formulation rather than using a lactose-free formula for children who are admitted to the hospital sick and severely malnourished, including those with diarrhea. Further research is needed to investigate whether a more radical reformulation of these feeds could be made while still providing the energy and nutrients needed by sick and severely malnourished children.

— Source: PLOS